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KMID : 0869620060230040318
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Journal of Korean Society of Hospital Pharmacists
2006 Volume.23 No. 4 p.318 ~ p.322
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Lee Kon-Hee
Choi Min-Kyu
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Abstract
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Carbamazepine (CBZ) and Valproic acid (VPA) are anticonvulsants used commonly in
children with epilepsy. Various adverse effects of CBZ and VPA have been reported in many previous studies, which included sleeping, drowsiness, weight gain, abdominal pain, anorexia, anemia, etc. The weight gain has been recognized as a common adverse effect of CBZ and VPA that leads to discontinuation or change to the other anticonvulsants in some patients. This adverse effect has been reported in various prevalence rates in some studies, respectively. So, we studied this adverse effect of CBZ or VPA in epileptic children of our hospital. We surveyed the incidence of weight gain, the revelation time to weight gain and the period of weight gain. And we did whether their weight gain is increased progressively or not. Finally, we evaluated the correlation between weight gain and dosage or serum level of CBZ, VPA. The weight gain is frequently revealed in the epileptic children with CBZ or VPA [CBZ 44.4%(12/27), VPA 66.7%(18/27)] (Table 2). This result is similar with studies by Corman CL et al.3). These weight gains occurred usually within 3 month of VPA or CBZ treatment like as the studies of Verity CM or Biotin V et al.5), 6). But some patient reported the delayed weight gain within 9 months of treatment, not within 3 months [CBZ group 30% (3/10), VPA group 7.7%(1/13)] (Table 2). If the weight gain was reported within 3 or 9 months of treatment, it was maintained longer than 10 months of treatment in the majority of patients [CBZ group 90%(9/10), VPA group 66.7%(6/9] (Table 2). And the progressive weight gain was reported in some patients [CBZ group 40%(4/10), VPA group 11.1%(1/9](Table 2). And, according to independent-t test, there was no significant correlation between weight gain and dosage, serum level in CBZ, VPA (Table 3). In addition, we used the binary logistic regression to identify the factor affecting the weight gain. There were no significant variables associated with the weight gain (gender, age, weight, weight percentile, dosage, serum level) 6)
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KEYWORD
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weight gain, carbamazepine, valproic acid
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